Analyses of drug concentrations in biological matrices
  (Toxicokinetics and Pharmacokinetics)
Drug concentrations in biological matrices obtained from various studies are determined and the relationships among the systemic exposure levels, dose levels and time course are analyzed. Analyses of drug concentrations are conducted in compliance with the GLP standards to provide highly reliable data.
 
 
Establishment of new analytical methods
  Optimum methods are established to analyze the test substances and major metabolites in biological matrices primarily using HPLC (Waters) and LC-MS/MS (API 3000, MDS SCIEX) systems.
Validation of analytical methods
  All established analytical methods are appropriately validated. Validation can be conducted in compliance with the GLP standards.
 
 
Analysis of the test substances
The identity (appearance, absorption spectra), content or titer, purity, stability, etc. will be analyzed in compliance with the GLP standards. Validation of the analytical method can be conducted in compliance with the GLP standards.
 
 
 
Analysis of dosing formulations
Dosing formulations (solutions, suspensions, diet admixtures) are analyzed for stability, homogeneity, concentrations, etc. in compliance with the GLP standards. The analytical methods are validated to ensure the accuracy of the analysis data. Validation of the analytical method can be conducted in compliance with the GLP standards.